After accidentally killing everyone in her class, Alice Wonder is now a patient in the Radcliffe Lunatic Asylum. No one doubts her insanity. Only a hookah-smoking professor believes otherwise; that he can prove her sanity by decoding Lewis Carroll's paintings, photographs, and find Wonderland's real whereabouts. Professor Caterpillar persuades the asylum that Alice can save lives and catch the wonderland monsters now reincarnated in modern day criminals. In order to do so, Alice leads a double life: an Oxford university student by day, a mad girl in an asylum by night. The line between sanity and insanity thins when she meets Jack Diamond, an arrogant college student who believes that nonsense is an actual science.